{
  "title": "Lp(a): computational candidate development",
  "recordType": "Nonconfidential program overview",
  "reviewDate": "2026-09-25",
  "objective": "Develop a small-molecule program intended for oral dosing that aims to prevent new Lp(a) particles forming through irreversible covalent engagement of apo(a).",
  "completedWork": [
    "Lead and alternative molecular designs",
    "Computational examination of recognition, reaction chemistry and exposure",
    "Draft experimental verification plan"
  ],
  "nextStep": "Synthesis and laboratory evaluation of productive engagement, functional persistence and selectivity.",
  "validationBoundary": "The proposed compound properties are not yet established experimentally. Oral delivery and clinical benefit remain development objectives.",
  "partnership": "Development and licensing discussions; selected scientific evidence can be reviewed under an appropriate mutual CDA.",
  "programRoute": "/programs/lpa/"
}