BioTwin · A Digital Fabric company

Run the entire drug discovery program in silico — before the first wet experiment.

BraidEra simulates a drug program end-to-end across every resolution layer — from quantum and atomic structure up through pathway, cell, tissue and organism — and carries cryptographically auditable evidence at every step. Walk in with a target. Walk out with a virtual shelf-ready dossier that converts cleanly into an IND-enabling program. The lab becomes confirmation, not discovery.

Request early access See how it works

Built on the Digital Fabric reality-twin substrate.

Discovery, not just screening

Topology-first modeling surfaces tractable targets and mechanisms that conventional pocket-based screening misses — including disordered and boundary-targetable proteins.

Evidence you can audit

Every prediction carries an evidence tier, a confidence vector, and a falsifiable criterion. Nothing is asserted that can't be traced and challenged.

Cross-scale by construction

One coherent model spans quantum to organism, so a finding at the atomic layer propagates its consequences — and its uncertainty — all the way up.

How it works

Three moves, repeated until the dossier is shelf-ready.

  1. 1

    Anchor to known science

    Every layer is calibrated against published results and reference databases. Predictions start tethered to ground truth, with confidence that reflects the supporting evidence.

  2. 2

    Simulate end-to-end

    Propagate a candidate through every resolution layer. Where the model can do what conventional methods can't, it produces a specific, testable prediction instead of a vibe.

  3. 3

    Expose and challenge the holes

    Open questions are first-class. Each gap is tracked as accepted, assumed, or challenged — and a challenged gap auto-generates the experiment that would falsify it.

Virtual shelf-ready means falsifiable

"Virtual shelf-ready" is only credible if every claim has a known-science anchor and a path to being proven wrong. BraidEra ties each claim dynamically to its supporting evidence; contradictions propagate through downstream confidence, and the system gets more confident — and more honest about its limits — as more validation lands.

  • Provenance and reversibility on every result
  • Per-claim confidence vectors, not single scores
  • Auto-designed falsification experiments for contested predictions
  • A living calibration record that compiles as you build

One model, every scale

From electrons to the whole organism — a single coherent substrate.

R0Quantum / electronic
R1Atomic / structural
R2Residue / segment
R3Domain / disorder
R4Complex / oligomer
R5Pathway / network
R6Cellular / phenotype
R7Tissue / ADMET
R8Organism / PK-PD

Bring us a target.

BraidEra is in active development with design partners. If you're working on a hard target — disordered, "undruggable," or resistance-prone — we'd like to hear about it.

Request early access

Or reach the parent team at digital-fabric.com.