Put target chemistry into its competing environment
An isolated target-reaction experiment is essential, but it leaves a separate question: what fraction of the opportunity survives the surrounding system? A competing-loss model tests how recognition, exposure and reaction assumptions affect target capture.
Find the parameter worth changing
If the model is limited by recognition, changing intrinsic reactivity may address the wrong problem. If exposure or a competing reaction dominates, a different experiment is needed. The output is a target-specific sensitivity analysis and a proposed design lever, conditional on the supplied rates and concentrations.
A worked computational investigation
In the Lp(a) program, BioTwin compared alternative molecular designs and their supporting assumptions, helping define a candidate program and a focused laboratory verification plan.
- Lp(a) investigation · Follow the target-specific computational case. Lp(a) investigation
Recognition, chemistry and exposure belong in the same question
Candidate design and kinetic modeling can examine recognition, reaction conditions and exposure together. Combining results requires the same candidate and compatible assumptions; separate favorable calculations do not establish a favorable joint result.
- Target-specific covalent design · Compare recognition, reaction conditions and exposure to prioritize candidate designs and their next laboratory tests. Target-specific covalent design
- Reversible capture · Follow reversal, clearance and recovery after engagement. Reversible capture